The Benefits of Astaxanthin as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient
Status:
Recruiting
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
Diabetes is one of the main health care problemsworldwide with 5% average increased number of
cases every year. According to International Diabetes Federation the prevalence of people
with diabetes reached the number of 425 million people in 2017 and estimated rising to 628
million by 2045. Painful Diabetic Neuropathy (PDN) is the most common complication of
diabetes affecting 90% of the patients. The symptoms of PDN include numbness, burning,
stabbing pain, paraesthesia or hyperesthesiaof both symmetrical limbthat could reduce the
quality of life. Several studies have found several therapeutic options to cope with pain in
the PDN, but the results are not as satisfactory due to the uncertain pathophysiology of the
disease and the limitations of the drug that can be administered because of
itspolypharmaceutical side effects. The causes of diabetic neuropathy not only include
vascular and metabolic factors but also Reactive Oxygen Species.
There are several therapeutic options that can be administered such as glycemic index
arrangement,foot care, symptomatic treatment, and predominantly pain therapy. According to
guidelines, there are drugs therapy thatrecommended for PDN, among others, Gabapentin,
Pregabalin and anticonvulsants until the pain subsides. Unfortunately, this treatment is only
aimed at relieving the symptoms of existing pain but not working on existing
pathophysiological mechanisms and fixing sensory deficits of neuropathy trials. Multi-target
treatments is needed to attenuate neuronal inflammation, oxidative stress and apoptosis.
Additional therapy can be an option to support healing and also the process of metabolic
pathophysiology that occurs due to rising glycemic index in the body that causes the work of
hexosamine pathway and trigger the formation of ROS and inflammation. There is evidence of
research demonstrating the neuroprotective effects of Astaxanthin as oxidative,
anti-inflammatory and anti-apoptotic agent. Not only that, Astaxanthin is also a good
supplement addition with no toxic effects when consumed, as well as hydrophilic and also
lipophilic nature which makes Astaxanthin can penetrate the BBB effectively.