The Benefits of Vitamin D 5000 IU as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient
Status:
Recruiting
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
Diabetic neuropathy is one of the micro-vascular complications of diabetes, 30-50% occurring
in all diabetic patients. This complication is one of the major cause of morbidity and
mortality in diabetic patientsand leading to a deterioration of their quality life. A
deficiency of vitamin D [25-hydroxyvitamin D, 25(OH) D] is common in patient with diabetes
and low concentrations are associated with the presence and severity of sensory neuropathy in
diabetes. Vitamin D deficiency has been shown to be an independent risk factor for diabetic
peripheral neuropathy (DPN). Topical and oral vitamin D have been reported significantly
reduce the symptoms and the pain of DPN. However, no case control clinical trial have been
reported that demonstrate the efficacy of vitamin D supplementation on the symptoms of DPN.
Painful in diabetic neuropathy is a major complication of diabetes, characterized by pain,
tingling, burning and cramps in the lower legs and feet with a signification reduction in
quality of life. Recently, there shown a significant reduction in the severity of painful
diabetic neuropathy after treatment with vitamin D. Patient with diabetes have a poor quality
of life compared to person without diabetes. The current study assessed the benefits of add
on oral vitamin D 5000 IU on diabetic neuropathy patient to pain impact in daily life.