The Bolus Dose of Dexmedetomidine (ED50) That Avoids Hemodynamic Compromise in Children

• Status: Completed
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Dexmedetomidine is a sedative drug that has many benefits when given to children under anesthesia, such as improved pain relief and reduced agitation following their surgery. It is usually given as an intravenous infusion over 10 minutes, to avoid the changes in heart rate and blood pressure that are occasionally seen when it is administered more quickly. However, this is often infeasible and usually inconvenient. The investigators aim to determine the dose of dexmedetomidine that can be given rapidly (over 5 seconds) without causing significant changes in heart rate and blood pressure. This will be the only study specific intervention.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of British Columbia
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• ASA I-II patients

• Elective surgery

• Planned general anesthesia with TIVA

• Planned insertion of LMA

• Ages ≥ 5 to < 10 years

Exclusion Criteria:

• Cardiac disease

• Cardiac rhythm abnormalities

• Chronic hypertension

• Predicted difficult intubation

• Contraindication to LMA use

• Weight < 5th centile or > 95th centile for age

• Pre-operative administration of anxiolytics (such as benzodiazepines or opioid analgesics)

• Hypersensitivity to dexmedetomidine or any other study medication