The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine

• Status: Completed
• Trial end date: 2017-03-21
• Target enrollment: 0
• Participant gender: All

Summary

This study compares the efficacy of low dose Ketamine versus Compazine for the control of headache in patients presenting to the Emergency Department.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Medical Center of Southern Nevada
• Treatments: Diphenhydramine; Ketamine; Ondansetron; Prochlorperazine; Promethazine

Criteria

Inclusion Criteria:

• Age 18 to 65 years

• Temperature < 100.4° F

• Diastolic Blood Pressure <104 mm Hg

• Normal neurological exam and mormal mental status

Exclusion Criteria:

• Pregnant or breastfeeding.

• Meningeal signs are present

• Acute angle closure glaucoma is suspected.

• Head trauma within the previous two weeks

• Lumbar puncture within the previous two weeks

• Thunderclap onset of the headache

• Weight more than 150 kg or less than 40 kg.

• Known allergy to one of the study drugs.

• History of schizophrenia or bipolar disorder.

• History of intracranial hypertension.

• Is a prisoner

• Patient declined informed consent

• Non-English speaking patient.

• Attending provider excludes patient