The Changes of Natural Killer Cells Frequency and Function During Antiviral Therapy
Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Pegylated interferon α-2a(Peg-IFN-α) not only inhibit viral replication, but also play an
important role in immune regulation, while Nucleoside analog(ue) drugs only inhibit viral
replication. In hepatitis B infection, NKs are the main effector cells in early antiviral
innate immune response. This study was aimed at investigating the changes of NKs frequency
and function, and the expression of costimulatory molecules during Peg-IFN-αand nucleoside
analog(ue) therapy.Meanwhile, investigators want to verify whether Peg IFN - alpha suppressed
the virus and the reduction of virus led to the recovery of NKs function, or Peg IFN - alpha
enhanced NKs function which gave rise to the decline of the virus.