The Chloroquine for Influenza Prevention Trial

• Status: Unknown status
• Trial end date: 2010-08-01
• Target enrollment: 0
• Participant gender: All

Summary

A randomised controlled trial to determine the efficacy of chloroquine for the prevention of influenza

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National University Hospital, Singapore
• Treatments: Chloroquine; Chloroquine diphosphate

Criteria

Inclusion Criteria:

• Age 18 -65

• Have the ability to provide informed consent

• If a woman of child-bearing potential, willing to use contraception for the period of the trial

Exclusion Criteria:

• Acute influenza-like illness at screening

• History of psoriasis, porphyria cutanea tarda, epilepsy, myasthenia gravis, myopathy of any cause, cardiac arrhythmias, or serious hepatic or renal disease

• Pregnancy or breast feeding

• Current use of medication with known serious hepatotoxic effects

• Current use of medication with known serious interaction with CQ: amiodarone, anticonvulsants, ciclosporin, digoxin, mefloquine, moxifloxacin

• Current severe depression (as indicated by current use of antidepressant medication)

• Known serious retinal disease

• Current or recent (within the past 30 days) participation in any other clinical intervention trial.

• Known G6PD deficiency

• Vaccination for influenza (seasonal or H1N1 strain) within the 3 months prior to screening