The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis
Status:
Completed
Trial end date:
2018-07-30
Target enrollment:
Participant gender:
Summary
The aim of the study is to investigate whether bosentan added to usual care improves arterial
stiffness after 3 months as measured as the pulse wave velocity (PWV) of the medium and large
arteries corrected for blood pressure changes in patients with systemic sclerosis (SSc) with
digital ulcers (DU). Patients will be randomized into a group with usual care and bosentan
(n=10) or usual care only (n=10). PWV will be assessed at baseline, 3 months and 12 months.