The Clinical Assessment of Nigella Sativa Oil vs Chlorohexidine as a Therapeutic Aid for Gingivitis, Effect on Gingival IL-6 and IL-18 and Antimicrobial Efficacy.

• Status: Completed
• Trial end date: 2021-02-28
• Target enrollment: 0
• Participant gender: Female

Summary

A double-blind randomized clinical trial was conducted for 14 days with 37 systemically healthy patients having chronic generalized gingivitis. The current study was designed to investigate the anti-inflammatory and antimicrobial efficacy of Nigella Sativa oil compared with chlorohexidine; assessing clinical parameters and gingival interleukin 6 (IL6) and interleukin 18 (IL18) levels and supra-gingival plaque analysis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ishrat Rahman
• Treatments: Chlorhexidine

Criteria

Inclusion Criteria:

• At least 20 natural teeth

• Patients with moderate to severe gingivitis

• No tooth attachment loss

Exclusion Criteria:

• Periodontitis

• Cigarette smokers

• Antibiotic therapy (within the last 3 months)

• Systemic diseases

• Pregnant women

• Lactating women

• Current orthodontic treatment

• Using an intra-oral artificial prosthesis

• Using other chemical agents as a mouthwash