The Clinical Study of Pitavastatin Treatment for Group of Mild to Moderate Alzheimer's Disease

• Status: Terminated
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Some studies suggest that statin medications may be effective against Alzheimer's disease. However, this has not been proven. The purpose of this study is to evaluate the efficacy of pitavastatin in patients with mild to moderate Alzheimer's disease and hypercholesterolemia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Osaka University
• Collaborator: Kowa Company, Ltd.
• Treatments: Ezetimibe; Pitavastatin

Criteria

Inclusion Criteria:

• Alzheimer's Disease patients (15 ≤ MMSE total score ≤ 23, CDR "1" or "2")

• Patients with hypercholesterolemia

• Patients who have taken donepezil more than 3 months stably

• Both patients and care-givers must be more than 20 years old

Exclusion Criteria:

• Women with pregnancy or breast-feeding

• Malignant tumor

• Cerebrovascular disorder or myocardial infarction prior to 12 weeks

• Heart failure [New York Heart Association (NYHA) class III or IV]

• Hepatic or renal dysfunction

• Severe hypertension

• Hypothyroidism, hereditary muscular disease, history of drug-induced myopathy

• Current involvement in another investigational drug study

• Alcoholism, drug abuse