The Combination Effect of Dexmedetomidine and Morphine in Postoperative Patient-Controlled Analgesia

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This study was designed to examine the analgesic and side effects of dexmedetomidine-morphine mixture for intravenous patient-controlled analgesia (PCA).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

1. Patients who sign informed consent to receive general anesthesia and postoperative analgesia with a PCA device

2. Age between 18-65 y/o

3. ASA physical status I-III

4. Scheduled surgical procedures: gynecological surgery (vaginal or abdominal total hysterectomy), general surgery (gastrectomy, hepatectomy, colon cancer) , orthopedic (spinal fusion or total knee placement), or neurosurgical (cervical decompression)

Exclusion Criteria:

1. Patients with a definite diagnosis of chronic pain syndrome, psychiatric disorders, or drug abuse (include opioids, NSAIDs, sedatives, antidepressants).

2. Use of sedatives, analgesics, antiemetics, or antipruritics within 24 hours before operation.

3. Patients with definite diagnosis of esophageal reflux syndrome.

4. Patients with the probability to be pregnant.

5. Intraoperative fentanyl use > 6 μg/kg.

6. Patients with significant bradycardia (HR < 60/min) and hypotension (SBP < 90mmHg) after the surgery.

7. The duration of surgery is longer than 6 hours.