The Comparative Efficacy and Safety of Two General Anesthesia Protocols Consisting of Fentanyl Plus Propofol Plus Rococuronium Plus Isoflurane Versus Ketamime Plus Magnesium Sulphate Plus Lidocaine Plus Clonidine Plus Propofol Plus Rococuronium Plus

• Status: Recruiting
• Trial end date: 2021-12-05
• Target enrollment: 0
• Participant gender: Female

Summary

Recently, a lot of side effects have been identified from the perioperative use of opioids. To remedy this, anesthesia research has recently focused on providing safe general anesthesia without opioids in a new concept or anesthetic technic called Opiod Free Anesthesia (OFA). Evidence on the effectiveness and safety of OFA is scarce in Africa, with no report from Cameroon.The aim of this study is to demonstrate the feasibility of an adapted OFA protocol as well as its efficacy and safety in very painful surgeries like gynaecology surgery in a low-resource setting.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Yaounde 1
• Treatments: Anesthetics

Criteria

Inclusion Criteria :

• American Society of Anesthesiology (ASA) grade I and II patients

• Patients undergoing an elective myomectomy, hysterectomy, ovarian cystectomy or total mastectomy.

• Patients who will be operated for benign pathologies or localized malignancies

Exclusion Criteria :

• Past history of allergy to any of the anesthetic drugs

• Refusal to consent to participate in the study