The Comparative Efficacy of Peri-articular and Intraarticular Tranexamic Acid in Total Knee Arthroplasty

• Status: Unknown status
• Trial end date: 2019-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Post-operative bleeding in total knee arthroplasty (TKA) can result in hypovolemic shock and unnecessity for allogenic blood transfusions. Intravenous and topical tranexamic acid (TXA) have been well established in reducing blood loss postoperatively. However, there are lack of data on peri-articular TXA injection during TKA. Therefore, the investigators conducted a three-arm prospective, randomized, controlled trial to compare the effectiveness of bleeding reduction of peri-articular TXA injections, intraarticular TXA injections and control group.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Thammasat University
• Collaborator: Krit Boontanapibul
• Treatments: Anesthetics; Anesthetics, Local; Tranexamic Acid

Criteria

Inclusion Criteria:

• Adult patients with osteoarthritis in need of a TKA

Exclusion Criteria:

• Inflammatory arthritis

• Post-traumatic arthritis

• A history of or current venous thromboembolic disease

• Any underlying disease of haemostasis, cirrhosis, chronic renal failure, patients on anticoagulants or strong antiplatelet drugs (e.g. warfarin, clopidogrel)

• Preoperative hemoglobin <10 g/dL or a platelet count < 140,000 /uL3

• Allergy to TXA