The Comparison of Remimazolam With Propofol in Core Body Temperature

• Status: Completed
• Trial end date: 2021-11-30
• Target enrollment: 0
• Participant gender: Male

Summary

1. Core body temperature is normally tightly regulated to within a few tenths of a degree. The major thermoregulatory defences in humans are sweating, arteriovenous shunt vasoconstriction, and shivering.

2. Inadvertent hypothermia often complicates prolonged surgery. In patients becoming sufficiently hypothermic, reemergence of thermoregulatory vasoconstriction usually prevents further core hypothermia.

3. The extent to which anesthetics reduce the vasoconstriction threshold depends on the type of drug and its concentration.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wonkwang University Hospital
• Treatments: Propofol; Remifentanil

Criteria

Inclusion Criteria:

ASA physical classification I-III, Robotic-assisted or laparoscopic (LRP) radical prostatectomy.

Exclusion Criteria:

Medications or had any implanted device that could affect cardiovascular function, heat balance Thyroid disease Dystautonomia Raynaud's syndrome Uncontrolled diabetes mellitus, or hypertension.