The Contribution of Incretin Hormones to Post-prandial Glucose Metabolism After Roux-en-Y Gastric Bypass

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The study is being undertaken to understand how the Roux-en-Y Gastric Bypass procedure can affect insulin secretion after meals. The hypothesis of this study is the Disposition Index is decreased in subjects who had previously undergone Roux-en-Y Gastric Bypass by glucagon-like peptide-1 (GLP-1) receptor blockade.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Adrian Vella
• Collaborators: National Center for Research Resources (NCRR); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Gastric Inhibitory Polypeptide; Hormones; Incretins

Criteria

Inclusion Criteria Roux-en-Y Gastric Bypass (RYGB)Subjects:

• Subjects who have undergone RYGB

Inclusion Criteria Healthy Subjects:

• Must match RYGB subjects in age, weight, and gender

• Subjects will be without active systemic illness

Exclusion Criteria all Subjects:

• Subjects <20 years old and >70 years old

• For Female Subjects: positive pregnancy text at the time of enrollment or study

• Subjects with functional or organic bowel symptoms.