The Diversity of Intestinal Microbiota in Patients With Different Sedative-hypnotics Undergoing Mechanical Ventilation

• Status: Withdrawn
• Trial end date: 2020-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Bidirectional communication between the CNS and the GI tract - the brain-gut axis - occurs both in health and disease.Patients with mechanical ventilation in ICU (ICU) often meet the necessary nutritional needs. These patients often appear varying degrees of intestinal flora imbalance, such as diarrhea, vomiting, abdominal distension and other complications, which exert negative effect on treatment and prolong hospitalization time.So far，whether the sedative drugs used for a long time in mechanically ventilated patients will affect the diversity of intestinal flora or not has not been reported.The effects of different sedative drugs on the intestinal flora diversity need further study.Therefore, this topic will used midazolam and dexmedetomidine to study the effect on the diversity of intestinal microbiota.Meanwhile，the research will provide a theoretical basis for rational use of mechanical ventilation and sedative drugs.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
• Treatments: Dexmedetomidine; Hypnotics and Sedatives; Midazolam

Criteria

Inclusion Criteria:

• patients who receive long-term (≥12 hours) mechanical ventilation after operation on admission to the ICU

• APACHEII score 12-20 points

• no receive other clinical trials in the near 3 months

• no acute infectious disease, psychosis or other disease

• volunteer people

Exclusion Criteria:

• known or suspected allergy to midazolam or Dexmedetomidine

• suspected pregnancy, gross obesity, hyperlipemia, moribund state

• history of alcoholism or intake of anti-anxiety drugs or hypnotics

• chronic renal failure

• coma by cranial trauma or neurosurgery or unknown etiology or status epilepticus

• unwillingness to provide informed consent by patients or their authorized surrogates following ICU admission.