The Diversity of Intestinal Microbiota in Patients With Different Sedative-hypnotics Undergoing Mechanical Ventilation
Status:
Withdrawn
Trial end date:
2020-11-01
Target enrollment:
Participant gender:
Summary
Bidirectional communication between the CNS and the GI tract - the brain-gut axis - occurs
both in health and disease.Patients with mechanical ventilation in ICU (ICU) often meet the
necessary nutritional needs. These patients often appear varying degrees of intestinal flora
imbalance, such as diarrhea, vomiting, abdominal distension and other complications, which
exert negative effect on treatment and prolong hospitalization time.So far，whether the
sedative drugs used for a long time in mechanically ventilated patients will affect the
diversity of intestinal flora or not has not been reported.The effects of different sedative
drugs on the intestinal flora diversity need further study.Therefore, this topic will used
midazolam and dexmedetomidine to study the effect on the diversity of intestinal
microbiota.Meanwhile，the research will provide a theoretical basis for rational use of
mechanical ventilation and sedative drugs.
Phase:
N/A
Details
Lead Sponsor:
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University