The Duration of the Suppressive Effects of Desloratadine on Allergen Prick Tests After Discontinuation (P04441)
Status:
Completed
Trial end date:
2006-05-01
Target enrollment:
Participant gender:
Summary
This is a randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single
center study in subjects with positive histamine skin prick test and a positive
RadioAllergoSorbent Test (RAST) (class > 2) to one of the tested standardized allergenic
extracts: tree pollen, cat dander, house dust mite, or a mixture of five grass pollens.
Subjects will be randomized to desloratadine 5 mg once daily, levocetirizine 5mg once daily,
or placebo once daily for 8 days of treatment followed by 11 days of skin testing after
discontinuation of the antihistamine treatment phase. The duration of the suppressive effects
of desloratadine on cutaneous allergen-induced wheal and flare responses after
discontinuation of a one-week treatment will be established.