The ED50 of DEX for Providing Sedation in Different Female Age Group

• Status: Unknown status
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

Dexmedetomidine(DEX) could provide dose-dependent sedation , analgesia , anti-anxiety and inhibition of sympathetic nerves and other effects. Because of its minimal impact on the respiratory , currently it was more and more widely used to sedate patients undergoing regional anesthesia.Many anesthetic pharmacokinetics and pharmacodynamics are often affected by age, and current studies with regard to the effects of age on dexmedetomidine pharmacodynamic are rare. This study was designed to explore the right DEX dose of different female Age of patients to produce suitable sedation.Dexmedetomidine be used in patients with combined spinal and epidural anesthesia for sedation,which is monitored by the Narcotrend,during the operation.The relation between Narcotrend index (NTI) and the depth of sedation for patients is also investigated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangzhou General Hospital of Guangzhou Military Command
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

1. ASA Ⅰ ~ Ⅱ patient undergoing lower extremity surgery

2. Written informed consent from the patient or the relatives of the participating patient.

3. BMI:18.0～25.0kg/m2

Exclusion Criteria:

1. Mental illness can not match

2. epidural anesthesia contraindicated

3. People who have Slow-type arrhythmias

4. People who were language or hearing impaired

5. Sensory block reached to T8 or higher.

6. People who had lung infection or sleep apnea syndrome.

7. Pregnancy

8. Chronic renal failure

9. Alcohol or drug abuse

10. Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug

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