The Effect Of A Controlled Daily Skin Care Regimen On Retinoic Acid Tolerance

• Status: Completed
• Trial end date: 2009-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Sun-damaged skin, caused by chronic exposure to ultraviolet (UV) light, is characterized by features such as wrinkling, uneven skin color, roughness and brown spots. An effective treatment for sun-damage that is commonly prescribed is topical retinoic acid (RA). However, the major drawback of topical RA use has been frequently observed irritation characterized by redness, dry skin and severe itching. In this study, we examine whether a daily skin care regimen comprised of an ultra mild cleanser and an effective moisturizer can help improve tolerance to RA treatment.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Michigan
• Collaborator: Unilever R&D
• Treatments: Tazarotene

Criteria

Inclusion Criteria:

• Caucasians between the ages of 40 and 90 with moderate to severe sun-damage on the face who are generally healthy may participate.

• You must demonstrate a previous history of retinoid intolerance (established through prior history and the 2-week retinoid treatment phase of this study).

• Women of childbearing potential must agree to use an accepted form of birth control for the entire duration of the study.

• You must live within a reasonable driving distance of Ann Arbor, Michigan, and/or be able to attend all of the scheduled appointments during the study.

Exclusion Criteria:

• You may not have used any topical or systemic retinoids in the past 6 months.

• Women who are pregnant or nursing may not participate.

• If you have a history of non-melanoma skin cancer on the face in the past 5 years, you may not participate.

• If you have any history of malignant melanoma you may not participate.

• If you have any other skin condition or facial hair that will interfere with the study evaluations, you may not participate.

• If you have a known sensitivity to any of the ingredients in the study cream or Dove products, you may not participate.

• If you are currently on special daily skin care regimens that include cleansing with Dove, Olay, Aveeno or Cetaphil liquid facial cleansers and using facial moisturizers more than twice a day you may not participate.