The Effect Of Ultrasound-guided Modified Pectoral Nerves Block Versus Ketamine Plus Magnesium Infusion On Analgesic Profile In Breast Cancer Surgeries

• Status: Recruiting
• Trial end date: 2021-04-15
• Target enrollment: 0
• Participant gender: Female

Summary

Background: Postoperative pain is one of the greatest patient concerns following surgery. However, general anesthesia cannot provide adequate postoperative pain control and the routine use of parenteral opioids aggravates postoperative sedation, nausea, emesis, impaired oxygenation and depressed ventilation.

Hypothesis:

The investigators assume that both ultrasound guided Modified Pecs Block and combination of Ketamine and Magnesium sulphate infusion can achieve better analgesia in major breast cancer surgery in the form of reducing total amount of intraoperative fentanyl requirement and reducing postoperative morphine requirement and improvement of postoperative VAS scores both at rest and during shoulder movement so we plan this study to evaluate this assumption

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cancer Institute, Egypt
• Treatments: Analgesics; Ketamine; Magnesium Sulfate

Criteria

Inclusion Criteria:

• female patients with American society of Anesthesia classification(ASA) II physical status undergoing major breast cancer surgery with axillary evacuation under general anesthesia.

• Patients' age from18 to 65 Years.

• Body mass index (BMI) are from 20 to 40 kg/m2.

Exclusion Criteria:

• Pregnant patients

• Patients having sensitivity or contraindication to test drugs or regional anesthesia.

• severe respiratory or cardiac disorders.

• history of psychological disorder.

• chronic pain .

• significant liver or renal insufficiency. .