The Effect and Mechanism of Respiratory Stimulant Doxapram on Facilitating Emergence

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The current study is designed to investigate the difference of plasma orexin A levels between doxapram group and controlled group at emergence time from sevoflurane-remifentanil anesthesia who will undergo elective lumbar surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital of Ningxia Medical University
• Treatments: Central Nervous System Stimulants; Doxapram; Respiratory System Agents

Criteria

Inclusion Criteria:

1. Participant is Adult (≥18 years old and ≤75 years old)

2. Participants with a Body Mass Index (BMI) 20-25 kg/m2

3. Participants with ASA physical status Ⅰor Ⅱ

4. Participants with Heart function rating Ⅰor Ⅱ

5. patients will undergo elective lumbar surgery and general anesthesia

6. The operation time is 2h to 4h.

Exclusion Criteria:

1. Participant is a pregnant woman or a nursing mother.

2. Participants have a history of narcotics allergic reactions.

3. indices of liver or kidney function is twice higher than normal.

4. Participants have a history or diagnosis of depression.

5. Participants have a history of Brain Trauma.

6. Participants have a history of narcotics addiction or drug addiction.

7. Participants or his family have an International Classification of Sleep Disorders diagnosis of obstructive sleep apnea syndrome.

8. patients are refuse this trail or are not able to sign informed consent. -