The Effect of 18-month Regimen Containing 6 Anti-tuberculosis Drugs for Patients With MDR-TB

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

WHO has recommended that multidrug-resistant tuberculosis (MDR-TB, defined as resistance to at least isoniazid (H) and rifampicin (R) be addressed as a public health crisis and enhance capacity to deliver effective treatment and care. According to the 2018 WHO TB Report, the overall treatment success rate of MDR-TB is 55% while much lower in China at just only 41% with the 24-month regimen. In order to further verify the safety and efficiency of optimizing shorter 18-month regimen containing 6 anti-TB drugs with MDR-TB patients,500 more patients will be enrolled and observed.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beijing Chest Hospital
• Treatments: Antitubercular Agents

Criteria

Inclusion Criteria:

• Is willing and able to give informed consent to participate in the trial treatment and follow-up.

• Is aged between 18 years and 70 years.

• Has a positive sputum culture result or a positive GeneXpert result.

• Has evidence of RR-TB or MDR-TB either by GeneXpert or culture-based drug susceptibility testing (DST).

• Non pre-XDR-TB or XDR-TB.

• Is willing to use effective contraception of women at childbearing age.

• Has had a chest X-ray that is compatible with a diagnosis of pulmonary TB.

Exclusion Criteria:

• pre-XDR-TB or XDR-TB.

• Has a known allergy to any drug of the regimen.

• Is currently taking or took part in another trial less than three months before the study initiation .

• Is HIV positive.

• Has abnormal ECG with QT prolongation over 430ms of men while 450 of women.

• Is critically ill, and in the judgment of the investigator, unlikely to take part in the study.Or has any condition (social or medical) which in the opinion of the investigator would make study participation unsafe.

• Is known to be pregnant or breast-feeding.

• Has severe cardiovascular diseases, such as heart failure, hypertension (poor blood pressure control), arrhythmia or post-infarction status.

• Has severe concomitant severe disease such as respiratory failure or cardiac insufficiency or liver and kidney injury with aspartate aminotransferase (AST) or alanine aminotransferase (ALT) more than 2.5 times the upper limit of normal or with serum creatinine(Cr)more than 1.3 times the upper limit of normal.

• Has Karnofsky score less than 50%