The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion
Status:
Completed
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
Chronically elevated free fatty acids impair insulin sensitivity and insulin secretion (ie
lipotoxicity) by a combination of oxidative stress, endoplasmic reticulum (ER) stress and
inflammation. This study will test whether alpha-lipoic acid, which has potent antioxidant
and anti-inflammatory properties, prevents or ameliorates lipotoxicity.