The Effect of Acute Lysine Administration on α-aminoadipic Acid (Sub-study)

• Status: Completed
• Trial end date: 2017-05-18
• Target enrollment: 0
• Participant gender: All

Summary

This sub-study aims to assess the effect and breakdown of lysine administration, specifically examining whether it leads to increased plasma 2-AAA in healthy humans.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Vanderbilt University Medical Center

Criteria

Inclusion Criteria:

• BMI 18 to <25 kg/m2

• Men and women ages 18-45 years

Exclusion Criteria:

• Current use of prescription medications (apart from hormonal birth control)

• Current use of amino acid supplements (including branched-chain amino acids) or supplemental protein (habitual consumption of protein powder, bars, shakes), and unwilling to temporarily discontinue use (1 week prior to study visit)

• Individuals who currently use tobacco products or have done so in the previous 30 days

• Prior or current cardiovascular disease, renal disease, or liver disease

• Diabetes mellitus (taking insulin, other anti-diabetic agents, or diet-controlled)

• Atrial fibrillation

• Bleeding disorder or anemia

• Positive pregnancy test

• Women who are breastfeeding

• Participation in another clinical trial within the previous 6 weeks prior to the study visit

• Inability to provide written informed consent

• Inability to fast for 8 hours