The Effect of Acyclovir Treatment of the Herpes Simplex Virus (HSV) Infection on HIV Levels in the Blood
Status:
Completed
Trial end date:
2005-06-01
Target enrollment:
Participant gender:
Summary
Part A: To evaluate the impact of HSV suppression with acyclovir ( ACV ) on HIV burden in
patients with asymptomatic HSV infection and at high risk for HSV reactivation.
Part B: To characterize the change in plasma HIV RNA levels and other measures of HIV burden
during and after a 10 day course of ACV treatment for acute HSV infection.
Approximately 70% of patients infected with HIV are concurrently infected with HSV. There is
new evidence to suggest that HSV may act as a co-factor in HIV disease progression. This
study will attempt to determine if the upregulation of HIV RNA that occurs during symptomatic
HSV reactivation also occurs during asymptomatic HSV reactivation and if suppression of HSV
will result in decreased levels of HIV RNA. There is a need to determine the patterns of
association between HSV and HIV.
Phase:
N/A
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)