The Effect of Adding Metformin to the Treatment of Hepatitis C

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Insulin resistance is known to adversely effect viral response to treatment in hepatitis C patients

We are aiming to study the effect of an insulin sensitizer, metformin, in viral response of hepatitis C to treatment with pegylated interferon and ribavirin in a double blind randomized controlled trial

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tehran University of Medical Sciences
• Treatments: Interferons; Metformin; Ribavirin

Criteria

Inclusion Criteria:

• chronic hepatitis C

• Iranian nationality

• Treatment naive

Exclusion Criteria:

• cirrhosis

• diabetes mellitus

• HBV/HIV coinfection

• contraindications of metformin, interferon, ribavirin

• severe medical conditions (e.g. CHF, CRF, psychosis, ...)

• not consenting