The Effect of Administration of Low Dose Adrenaline During Surgery on Bleeding During Hip Surgery

• Status: Completed
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effect of intraoperative administration of low-dose adrenaline on intraoperative blood loss in patients undergoing hip surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Treatments: Epinephrine; Epinephryl borate; Racepinephrine

Criteria

Inclusion Criteria:

• Age > 18 years.

• Scheduled for primary unilateral hip arthroplasty

• Able to give consent

Exclusion Criteria:

• Allergy towards adrenaline

• Current treatment with: ADP receptor inhibitors or Vitamin K antagonists (within 5 days), Factor Xa inhibitors or Thrombin inhibitors (within 1 day), heparin (excluding low molecular weight heparin for perioperative thromboprophylaxis).

• Current treatment with tricyclic antidepressants

• Use of MAO inhibitors (within previous 14 days) or COMT inhibitors (within 2 days).

• Acute coronary syndrome / myocardial infarction within the previous 6 months.

• not willing to accept blood transfusion

• Participation in other clinical trial within previous 30 days

• Women of childbearing age (without menopause for at least 12 months)

• Glaucoma

• Pheochromocytoma

• Low serum K+ (< 3.0 mmol/L)

• Thyrotoxicosis

• Digoxin intoxication

• Alcohol og drug abuse (investigators judgement)