The Effect of Allergen Inhalation on Sputum Myeloid and Plasmacytoid Dendritic Cells in Mild Atopic Asthmatics

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Summary:

A picture is emerging of dendritic cells migrating through the blood to the airways following allergen inhalation in atopic asthmatics. Although the Koh and McCarthy articles present novel findings, both do not provide a comprehensive view of sputum DCs following allergen challenge. Therefore, the proposed study will examine the kinetics of mDCs and pDCs in the induced sputum of atopic asthmatics following inhalation of allergen.

Hypothesis:

Following allergen challenge, sputum myeloid and plasmacytoid DCs will migrate into the airway lumen in atopic asthmatics during the timeframe of the late asthmatic response.

Objective:

The objective of this study is to examine the kinetics of dendritic cells in induced sputum following allergen challenge in atopic asthmatic subjects.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hamilton Health Sciences Corporation

Criteria

Inclusion Criteria:

• Mild atopic asthmatics, presently well controlled on ß2-agonists.

• Non-smokers.

• Baseline FEV1 more than 70% of predicted normal.

Exclusion Criteria:

• Airway infection during the last 4 weeks.

• Exacerbation during the last 4 weeks.

• Inhaled or oral steroids during the last 4 weeks.

• Antihistamines during the last 48 hours.

• Asthma medication other than inhaled and/or oral ß2-agonists during the last 4 weeks.

• Pregnant women.