The Effect of Amlodipine and Lisinopril on Retinal Autoregulation in Type 1 Diabetes

• Status: Completed
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the effect of two antihypertensive drugs on retinal vessel diameter in young type 1 diabetics. The retinal vessel analyzer (RVA) was used to investigate how the drugs affected vessel diameter, when the subjects were exposed to an increase in blood pressure, induced by isometric muscle contraction and when they were stimulated by flickering light.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Aarhus
• Collaborator: Velux Fonden
• Treatments: Amlodipine; Lisinopril

Criteria

Inclusion Criteria:

• Type 1 diabetes

• 18-35 years of age

• Simplex retinopathy at last screening (Less than 10 retinal haemorrhages at the nearest ordinary screening examination)

• normotensive (BP not above 160 mmHg systolic or 100 mmHg diastolic)

Exclusion Criteria:

• Pregnancy

• Systolic Bloodpressure above 160 mmHg

• Diastolic bloodpressure above 100 mmHg

• Retinopathy grade higher than simplex retinopathy

• Prior retinal laser photocoagulation