The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response

• Status: Completed
• Trial end date: 2019-12-30
• Target enrollment: 0
• Participant gender: All

Summary

The effect of surgery, in contrary to critical illness, on muscle weakness hasn't been thoroughly investigated. Recent data suggest that elective surgery may also induce muscle weakness. The neuro-endocrine stress response could be involved in the pathophysiology. Whether the mode of anesthesia/analgesia can influence muscle weakness, by influencing the neuro-endocrine stress response is unknown. Gaining insight in this matter could affect quality of care and benefit patient recovery and satisfaction.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ziekenhuis Oost-Limburg
• Treatments: Anesthetics

Criteria

Inclusion Criteria:

• Aged 18 years or older.

• Scheduled for elective total hip arthroplasty or hemicolectomy.

Exclusion Criteria:

• Lack of informed consent or inability to give informed consent.

• Urgent surgery, such as hip fracture.

• Contra-indications for spinal or epidural analgesia, including but not limited to:

• Infection at the site of puncture.

• Coagulopathy.

• Severe hypovolemia.

• Severe aortic valve stenosis (cross sectional area < 1,3 cm2).

• Severe mitralis valve stenosis (cross sectional area < 1,0 cm2).

• Increased intracranial pressure.

• Pre-existing neurological condition.

• Severe spine deformity.

• Sepsis.

• Body mass index (BMI) > 35 kg/m2

• Hypersensitivity or known allergic reactions to any products used for anesthesia.

• History of chronic opioid analgesics use.

• Preoperative use of steroids:

• Including, but not limited to: injection of hydrocortisone < 3 months before surgery.

• Preexisting muscle disease

• Including, but not limited to: Steinert's disease, amyotrophic lateral sclerosis (ALS), Duchenne dystrophy, amputation of dominant arm or hand.