The Effect of Anticholinergics on Cognitive Function in the Elderly

• Status: Completed
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

Anticholinergic medication is used to treat overactive bladder (OAB). A known side effect of this medication is cognitive dysfunction. OAB is more prevalent in the elderly population - a group that also has a higher baseline risk of cognitive dysfunction. Our objective is to evaluate the effect of an anticholinergic medication on cognitive function in elderly women.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of North Carolina, Chapel Hill
• Collaborator: American Urogynecologic Society
• Treatments: Cholinergic Antagonists; Trospium chloride

Criteria

Inclusion Criteria:

• Female 50 or older

• Diagnosis of OAB (ICS definition)

• English literacy

• Ability to swallow oral medication

• Cognitive ability to give consent

Exclusion Criteria:

• Dementia/Depression/Delirium

• Current anticholinergic use (requires 2 week washout period)

• Current cholinesterase

• Urinary or gastric retention

• Severe decreased gastrointestinal motility

• Uncontrolled narrow-angle glaucoma

• Myasthenia gravis

• Diagnosis fo renal impairment (creatinine clearance <30 mL/min)