The Effect of Aspirin on Angiogenesis Proteins in Women on Tamoxifen Therapy
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
Changes in major angiogenic proteins have been seen following initiation of tamoxifen and
aromatase inhibitor therapy in women with breast cancer. One source of these proteins is the
circulating platelet pool. The investigators hypothesize that in addition to their
anti-platelet properties, agents such as aspirin can be used as targeted anti-angiogenesis
therapy. The investigators will determine the influence of aspirin on the release of
angiogenic proteins from platelets in 35 patients with breast cancer.