The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury

• Status: Unknown status
• Trial end date: 2019-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a double-blind, placebo-controled, randomized trial to investigate if aspirin pre-treatment has anti-inflammatory effects in a model of acute lung injury induced by inhaled endotoxin (LPS) in healthy human volunteers.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Belfast Health and Social Care Trust
• Collaborators: Northern Ireland Clinical Trials Unit; Queen's University, Belfast; The Intensive Care Society United Kingdom
• Treatments: Aspirin

Criteria

Inclusion Criteria:

• Healthy subjects

Exclusion Criteria:

• Age < 18 years

• Pregnancy or breast feeding or woman of childbearing potential not using

• adequate contraception.

• Participation in a clinical trial of an investigational medicinal product within 30 days

• Consent declined Aspirin or non steroidal anti-inflammatory (NSAID) use in the past 4 weeks

• History of asthma

• Known aspirin or NSAID hypersensitivity

• History of peptic ulcer disease

• Platelet count < 150 x 106/ml

• Aspirin resistance