The Effect of Bitter Taste Receptor Agonists on The Gastrointestinal Tract, Hunger and Food Intake
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
In this study, the investigators aimed at evaluating the role of bitter taste receptors in
the gastrointestinal tract (GIT). Intragastric or intraduodenal administration of denatonium
benzoate (DB) or quinine hydrochloride were compared with placebo administration for their
effects on lingual sensitivity, gastrointestinal motility (both in the fasted and fed state),
gut hormone release (motilin, ghrelin, glucagon-like peptide-1 (GLP-1) and cholecystokinin
(CCK)) and food intake. Differences between lean and obese subjects will be evaluated.