The Effect of Caffeine on Ischemic Preconditioning
Status:
Completed
Trial end date:
2006-01-01
Target enrollment:
Participant gender:
Summary
Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia
render the (myocardial) muscle more resistant to a subsequent more prolonged period of
ischaemia and reperfusion. Animal studies have provided evidence that adenosine receptor
stimulation is an important mediator of IP. As caffeine is an effective adenosine receptor
antagonist already at concentrations reached after regular coffee consumption, we aimed to
assess whether caffeine impairs IP in humans in vivo. We used a novel and well-validated
model to study IP in humans: 99m-Tc-annexin A5 scintigraphy in forearm skeletal muscle.
24 healthy volunteers were randomly assigned to either caffeine (4 mg/kg/iv in 10 minutes) or
saline before a protocol for IP.
Phase:
N/A
Details
Lead Sponsor:
Radboud University
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development