The Effect of Central Insulin on Insulin Sensitivity and Energy Metabolism
Status:
Unknown status
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
Insulin has a direct effect on the energy metabolism of the brain under basal conditions and
has an effect on the hepatic glucose production, lipid metabolism and the secretion of
various hormone. The effect of intranasal insulin on peripheral metabolism in humans
supposedly is mediated by the vagus nerve.
The purpose of this study is to determine whether central insulin influences the human
peripheral insulin sensitivity of liver and muscle and whether vagus nerve stimulation can
mimick this effect.