The Effect of Cetirizine on Bronchoconstriction

• Status: Unknown status
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effect of cetirizine, an oral antihistamine, on wheezing in patients with allergic rhinitis. Patients presenting to the pediatric emergency department who have a history of allergic rhinitis and who are wheezing will be asked to participate. Half of patients will receive a dose of cetirizine and the other half will receive placebo and their response will be monitored over the course of their emergency department visit with vital signs, physical examinations, and measurement of bronchoconstriction with spirometry.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: New York City Health and Hospitals Corporation
• Treatments: Cetirizine

Criteria

Inclusion Criteria:

• History of allergic rhinitis

• Wheezing

Exclusion Criteria:

• Use of antihistamine within the past 72 hours

• Chronic Pulmonary Condition other than asthma

• Other contraindication to cetirizine

• Severe asthma exacerbation requiring resuscitation