The Effect of Chlorhexidine on the Oral and Lung Microbiota in Chronic Obstructive Pulmonary Disease
Status:
Completed
Trial end date:
2020-01-01
Target enrollment:
Participant gender:
Summary
Determine the effect of twice-daily chlorhexidine oral rinse on oral and lung microbiota
biomass in subjects with chronic obstructive pulmonary disease (COPD) with chronic
bronchitis. Our primary outcome will be to compare the microbiota biomass (number of bacteria
as measured by 16S rRNA copy number) of induced sputum and the oral cavity before and after 8
weeks of twice-daily chlorhexidine oral rinse (n=25) compared to controls (n=25) using qPCR
and next-generation sequencing of the bacterial 16S rRNA gene comparing total bacterial
biomass
Phase:
Phase 2
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute
Collaborators:
Flight Attendant Medical Research Institute Veterans Medical Research Foundation