The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients Receiving Total Knee Arthroplasty

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The interaction of analgesia and sedation ot their effect on the prognosis of surgical patients still need to be elucidated.Currently, how to optimize intra-operative Analgesia and sedation to improve the prognosis of surgical patients is still a mystery.Intra-operative nerve block provided regional analgesia of the operated knee, which reduced the dosages of sedatives and analgesics.Based on a pilot study,the investigators found a decrease of post-operative adverse composite outcomes with the use of continuous femoral nerve block (2% versus 7%) ,therefore, the investigators postulate that general analgesia with lighter sedation in combination with peripheral nerve block could reduce the post-operative morbidity compared with deeper sedation.This randomized controlled trial is designed to test this hypothesis in patients receiving unilateral knee arthroplasty.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Min Su
• Treatments: Anesthetics; Lidocaine; Ropivacaine

Criteria

Inclusion Criteria:

• Men and women over the 18 years and younger than 80 years old

• Scheduled to receive selective unilateral knee replacement.

Exclusion Criteria:

• Bilateral knee replacement

• The secondary knee revision and knee surgery not interfering with articular joint cavity (wound debridement and suture)

• American Society of Anesthesiology (ASA) classification of anesthesia risk IV and V grade

• Body mass index higher than 35

• Coagulation dysfunction, which is assessed by activated partial thromboplastin time (APTT) higher than the upper limit by 10s; prothrombin time (PT) higher than the upper limit by 5s; International Normalized Ratio (INR) higher than 1.3, or any of criteria met above;

• Pre-operative hypoxia (SpO2< 90% or PO2<60 mmHg)

• Pre-operative hypercapnia (PCO2> 50 mmHg)

• Local infection of puncture sites

• Neurological diseases and pre-operative psychological disorders

• Uncontrolled general infection

• Intra-operative cardiac arrest.