The Effect of DPP4 Inhibitor on Vasclular Healing

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluate the effect of dipeptidyl-peptidase 4 inhibitor on vascular healing after biodegradable polymer based sirolimus eluting stent implantation in diabetic pateints.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chung-Ang University
• Treatments: Dipeptidyl-Peptidase IV Inhibitors; Sitagliptin Phosphate

Criteria

Inclusion Criteria:

• Non-ST segement elevation acute coronary syndrome

Exclusion Criteria:

• Left main disease

• Known hypersensitivity or contraindication to any of the following medications:

Heparin, aspirin, clopidogrel, sirolimus, siptagliptin and statin

• Congestive heart failure (patients with LVEF <30% or cardiogenic shock)

• Uncontrolled myocardial ischemia (repeated chest pain or dyspnea after revascularization)

• Uncontrolled ventricular arrhythmia

• History of malignancy with chemotherapy

• Serious hematologic disease (e.g. CML, MDS)

• Current infectious disease needs antibiotics therapy

• Creatinine level >1.5 mg/dL or dependence on dialysis

• Other severe concurrent illness (e.g. active infection, malignancy).

• Life expectancy of less than one year

• Pregnancy or women with potential childbearing

• Type I DM

• Treatment with insulin

• History of pancreatitis

• Who cannot read the informed consent form (e.g. illiteracy, foreigner)