The Effect of Deep Inhalation on Mannitol Responsiveness

• Status: Completed
• Trial end date: 2019-04-30
• Target enrollment: 0
• Participant gender: All

Summary

The study will assess how the inhalation technique used (deep inhalations versus tidal breathing) influences the results of a mannitol challenge test and a methacholine challenge test, if at all.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Saskatchewan
• Treatments: Mannitol; Methacholine Chloride

Criteria

Inclusion Criteria:

• signed informed consent

• men and women between 18 and 75 years of age

• FEV1 at first measurement of greater than or equal to 65% predicted

• methacholine provocative concentration causing a 20% in FEV1 at screening that is less than or equal to 16mg/ml

• generally good health

• stable asthma

Exclusion Criteria:

• respiratory infection within 4 weeks of screening visit

• worsening of asthma within 4 weeks of screening visit

• lung disease other than asthma

• significant medical comorbidity

• current smoker or ex-smoker with significant smoking history

• currently pregnant or breastfeeding