The Effect of Desflurane on Postopertative Cognitive Dysfunction

• Status: Recruiting
• Trial end date: 2023-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effect of desflurane on postoperative cognitive dysfunction

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beijing Chao Yang Hospital
• Treatments: Desflurane; Propofol

Criteria

Inclusion Criteria:

• 1. Written consent given

• 2. Scheduled to undergo elective non-cardiac surgeries under general anesthesia

• 3. ASA Physical Score I-III

Exclusion Criteria:

• 1. Patients with a history of neurological disease, such as Alzheimer disease.

• 2. Patients with a history of psychiatric disease

• 3. Patients with a medication history of antipsychotic drugs.

• 4. Unable to complete neuropsychological testing including patients with severe visual or hearing impairment.

• 5. Patients with preoperative delirium.

• 6. Patients who have severe adverse events, such as cardiac arrest.

• 7. Patients who preoperative MMSE score are below 20;

• 8. Patients who undergo second operation in a short period.