The Effect of Dexamethasone on Pain After Total Knee Replacement Surgery

• Status: Terminated
• Trial end date: 2018-01-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine, if a single-dose of dexamethasone given during the operation, alleviates pain after knee replacement surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Oulu
• Treatments: BB 1101; Dexamethasone; Dexamethasone acetate

Criteria

Inclusion Criteria:

• primary total knee replacement surgery

• ASA (american society of anesthesiologists) class 1-3

Exclusion Criteria:

• severe coronary artery disease, heart failure, kidney failure

• insulin-dependent DM (diabetes mellitus), poorly controlled type II DM

• gastric/duodenal ulcer

• allergy/contra-indication for any drug used in the study

• corticosteroid use during last 3 months

• preoperative use of opioid drugs (excl. codeine, tramadol)

• neuropathy/sensory impairment of lower limbs

• lack of co-operation, e.g. inability to use a PCA (patient controlled analgesia)-device