The Effect of Dexmedetomidine on Brachial Plexus Block for Shoulder Surgery

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether a small dose of Dexmedetomidine, when given either intravenously or as part of the interscalene nerve block solution, prolongs pain relief following shoulder surgery compared to local anesthetic solution alone.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Women's College Hospital
• Treatments: Dexmedetomidine; Ropivacaine

Criteria

Inclusion Criteria:

• unilateral surgical shoulder procedures under general anesthetic

• English speaking patients

• ASA I-III patients

• BMI <38 kg/m2

Exclusion Criteria:

• proximal clavicular surgery

• preexisting neurological deficits or peripheral neuropathy

• known coronary heart disease, congestive heart failure, cardiomyopathies, or arrhythmias

• known cerebrovascular disease

• baseline heart rate <60 beats per minute or baseline systolic blood pressure <100 mm Hg

• medications that reduce heart rate (as beta-blockers, calcium blockers) known liver dysfunction or existing diseases known to cause hepatic or renal impairment

• severe bronchopulmonary disease

• local infection

• contra-indication to regional anesthesia (bleeding, coagulopathy)

• chronic pain disorders

• current use of over 30mg oxycodone or equivalent per day

• contraindication to a component of multimodal analgesia

• allergy to local anesthetics or dexmedetomidine

• history of significant psychiatric conditions that may affect patient assessment

• pregnancy

• inability to provide consent