The Effect of Different Drugs in the Prevention of Tooth Sensitivity Caused by Tooth Bleaching Treatment.
Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
Background: The administration of the intra-oral drugs was not capable of reducing this side
effect, maybe the use of two analgesics may to present better analgesic effect to avoid the
bleaching-induced tooth sensitivity (TS). Methods: A triple-blind, parallel-randomized
clinical trial was conducted with 114 health patients who received either a placebo or an
association of ketorolac tromethamine/acetaminophen. The first doses of two analgesic
(Acetaminophen 750 mg/ Ketorolac Tromethamine 10 mg) or placebo was administered 1 h before
the in-office bleaching (35% hydrogen peroxide), and extra doses were administered every 8 h
for 48 h. The TS was recorded using 0-10 visual analog scale and a 0-4 numeric rating scale
in different periods: during bleaching and from 1 h up to 6h, from 12 h up to 18h, from 18h
up to 24 h, from 24h up to 48 h post-bleaching. The color was measured before and one month
after dental bleaching with a visual shade guide Vita Classical, Vita Bleachedguide 3D-Master
and spectrophotometer Vita Easyshade (Vita Zahnfabrik). The absolute risk of TS was evaluated
by Fisher's exact test. Data of TS intensity with NRS scale of the two groups were compared
with Mann-Whitney and Friedman tests, while data from the VAS scale were evaluated by two-way
repeated measures ANOVA and Tukey's test for pairwise comparison. The color changes between
groups were compared using a Student t-test (α = 0.05).
Phase:
Phase 3
Details
Lead Sponsor:
Universidade Estadual de Ponta Grossa
Collaborators:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Universidade Estadual do Oeste do Paraná