The Effect of Direct Antiviral Therapy on Hepatitis c Virus-related Thrombocytopenia

• Status: Unknown status
• Trial end date: 2019-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Autoimmune thrombocytopenic purpura is an immunological disorder characterized by increased platelet destruction due to presence of anti-platelet antibodies. Hepatitis C virus infection, which is one of the most common chronic viral infections worldwide, may cause secondary chronic immune thrombocytopenic purpura. It seemed to play a pathogenic role in autoimmune thrombocytopenic purpura. Moreover, the successful response (negative hepatitis C virus - ribonucleic acid) to tapered steroids and antiviral therapy was useful to revert thrombocytopenia

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Antiviral Agents; Ledipasvir; Ledipasvir, sofosbuvir drug combination; Sofosbuvir

Criteria

Inclusion Criteria:

• Hepatitis C virus infection and thrombocytopenia before treatment

Exclusion Criteria:

• Infection Hepatitis B virus

• Hypersplenism

• Diseases affecting Bone marrow

• Major clotting factors abnormalities eg. Disseminated intravascular coagulopathy, severe Prothrombin deficiency