Overview

The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm

Status:
Completed

Trial end date:
2005-08-01

Target enrollment:
0

Participant gender:
All

Summary

The matrix metalloproteinase-9 (MMP-9) is considered to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline has direct MMP-9 inhibiting properties in vitro, and it effectively suppresses AAA development in rodents. Observed inhibition of AAA progression, and contradictory findings in human studies evaluating the effect of doxycycline therapy on aortic wall MMP-9 suggest that the effects of doxycycline extend beyond MMP-9 inhibition, and that the effect may be dose dependent.

Phase:

Phase 2

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Leiden University Medical Center

Treatments:

Doxycycline

Criteria

Inclusion Criteria:

- Elective open aneurysm repair

Exclusion Criteria:

- Severe kidney and liver dysfunction