The Effect of Dronabinol on the Acquisition and Consolidation of Trauma-Associated Memories
Status:
Recruiting
Trial end date:
2023-08-31
Target enrollment:
Participant gender:
Summary
The aim of the current project is to investigate the impact of an activation of the
cannabinoid system with an exogenous cannabinoid dronabinol (delta-9-tetrahydrocannabinol) on
the formation of intrusive memories after analog trauma.
A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy
participants. In a double-blind placebo-controlled study, the impact of exogenous dronabinol
on intrusive symptoms during exposure to a trauma film will be examined. The primary
hypothesis is that exogenous oral dronabinol will decrease the number of intrusive memories
recorded in the four days following experimental trauma compared with placebo controls.
This project will contribute to the current understanding of intrusive memory formation in
PTSD and may guide the development of future pharmacological preventions.