Overview

The Effect of Dupilumab on Lung Function and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma

Status:
Recruiting

Trial end date:
2022-10-01

Target enrollment:

Participant gender:

Summary

Primary Objective: o To assess the effect of dupilumab on lung function and related changes in airway volumes detectable by functional respiratory imaging Secondary Objective: - To evaluate the effect of dupilumab at Week 24 on bronchodynamics, hyperinflation, airway resistance, airway wall thickness, ventilation defects and mucus plugging derived from high-resolution computed tomography (HRCT) scans, patient-reported outcomes, FeNO and spirometry. - To evaluate safety of dupilumab

Phase:

Phase 4

Details

Lead Sponsor:

Sanofi

Collaborator:

Regeneron Pharmaceuticals