The Effect of Early Radiofrequency Turbinate Reduction on Persistent Allergic Rhinitis
Status:
Completed
Trial end date:
2020-02-01
Target enrollment:
Participant gender:
Summary
The primary outcome of this study is to evaluate the effect of radiofrequency turbinate
reduction as an initial treatment on clinical improvement (using visual analogue scale based
on total nasal symptoms score, peak nasal inspiratory flow, and turbinate size using ImageJ),
inflammatory mediators (ELISA from nasal secretions was performed to measure ECP, IL-5, and
HSP-70), and remodeling markers (through nasal biopsy followed by immunohistochemistry
examination to evaluate MMP-9, TIMP-1, and PAI-1).
In this randomized, controlled trial, 32 patients with moderate-severe persistent AR were
randomly divided into 2 groups. Intervention group received radiofrequency turbinate
reduction followed by intranasal steroid and antihistamine H-1(AH-1), control group received
intranasal steroid and AH-1. Both groups were evaluated for clinical improvement in week 4
and 8 after treatment, inflammatory mediators and remodeling markers in week 4 after
treatment.