The Effect of Erythromycin on Occurrence of Leaks From Cervical Esophageal-Gastric Anastomosis After Trans-Hiatal Esophagectomy

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Cervical anastomotic leak is one of the most common complications after trans-hiatal esophagectomy.

Hypothesis: An early post operative administration of a pro-kinetic dosage of erythromycin will reduce leak occurrence.

Design: This is a prospective, randomized, double blind, placebo controlled study.

Number of patients: 30.

Inclusion Criteria:

• Patients after trans-hiatal esophagectomy

Exclusion Criteria:

• Allergy to erythromycin

• Use of phenothiazine

• QT prolongation

• Liver function test (LFT) abnormalities

• Myasthenia gravis

• Cardiomyopathy

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kaplan Medical Center
• Treatments: Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin stearate

Criteria

Inclusion Criteria:

• Patients after trans-hiatal esophagectomy

Exclusion Criteria:

• Allergy to erythromycin

• Use of phenothiazine

• QT prolongation

• Liver function test (LFT) abnormalities

• Myasthenia gravis

• Cardiomyopathy